New Studies Surrounding Sleep Cycles

A long night’s sleep activates longevity genes in mice. 

Recent studies have demonstrated that the circadian clock controls rhythmic synthesis of the cofactor nicotinamide adenine dinucleotide (NAD(+)) and activity of NAD(+)-dependent sirtuin deacetylase enzymes to regulate mitochondrial function across the circadian cycle.

Here are just a few things we know for sure about how sleep works at a cellular level: 

  • Circadian rhythms are processes that have a 24-hour cycle 
  • The production of an essential molecule called nicotinamide adenine dinucleotide (NAD) is one of those processes  
  • Metabolic stresses like time zone disruption can impact NAD levels, causing a disruption in other circadian rhythms  
  • Out of sync circadian rhythms can lead to jet lag and sleep deprivation 

When your NAD levels stick to their pattern of rising and falling within their 24-hour cycle, it’s easier for other biological processes to maintain their circadian rhythms as well.

Circadian control of NAD+ levels in liver has been shown to control rhythmic oscillations in the activity of NAD+-dependent sirtuindeacetylase enzymes (SIRTs), which are critical regulators of metabolic fuel switching in response to altered fuel availability.

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