The Study That Got Researchers Excited About Nicotinamide Riboside

In 2016, one clinical study proved that nicotinamide riboside (NR) could effectively increase NAD levels in humans. 

We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD+ metabolome in the first clinical trial of NR pharmacokinetics in humans.

We knew nicotinamide riboside (NR) was an effective NAD precursor found in trace amounts in cow’s milk. This 2016 study showed NR was effective at increasing NAD levels in humans as a vitamin supplement. 

Here are the other things we know about nicotinamide riboside (NR):

We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD+, is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD+ repletion.

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