How We Know NAD Declines With Age

This clinical study got scientists thinking about NAD and healthy aging.


The Massudi article from 2012 is often cited when looking at the potential of nicotinamide adenine dinucleotide (NAD) to improve human health as we age. That’s because there’s a lot of promising research around the connection between lower NAD levels and the aging process as a whole.

Here are just a few of the reasons why teams like Massudi’s are interested in the effects of NAD levels on human health:

  • NAD levels decline by up to 50% in human skin tissue between the ages of 40–60

  • NAD depletion may play an important role in the aging process [1]

  • Preclinical studies show a correlation between lower NAD levels and some age-related health conditions

Read all the science and research surrounding NAD at:

A strong negative correlation was observed between NAD+ levels and age in both males and females.
— Massudi, H., et al., 2012

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