Sick Of Athletic Supplement Scams? Try This Instead.

The sports world is flooded with products over-promising results to both professional and aspiring athletes alike. But one thing every athlete needs to perform at their best is cellular energy. And one supplement that’s been shown to increase cellular energy production is a breakthrough form of vitamin B3 known as TRU NIAGEN®.

 
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Give Your Cells What They Need

Athletes demand a lot from their bodies, and in turn from their cells. Every one of those cells relies on a molecule called NAD (nicotinamide adenine dinucleotide) to power metabolism, be resilient to stress, and maintain health.

Despite its importance, however, NAD is not a constant resource. The life of an athlete (professional or otherwise) is full of metabolic stressors that can contribute to the decline of this vital molecule. This can leave the body’s most important functions fighting over a dwindling supply of NAD, just when they need it most.

Tru Niagen is shown in multiple clinical studies safely and effectively increase NAD.

NAD Is An Essential Athletic Resource

Lately, there’s been a resurgence within the scientific community to reexamine just how important NAD is to overall cellular health. [1-4] Here are some key ways NAD works to support cellular health and performance of athletes.

Cellular Energy + Repair

Our cells require a constant supply of energy to perform at their best. NAD is an essential part of energy-generating processes. NAD also promotes cellular repair and plays an important role in keeping our cellular powerhouses, the mitochondria, working efficiently. [5-7]

Muscle Function + Recovery

For starters, NAD helps generate the cellular energy required for muscle contractions. It’s also been estimated that endurance runners regenerate their body weight in ATP over the course of a two-hour marathon. NAD is central to this process, both during exercise and the recovery process. [8-10]

Circadian Rhythms

We all know that poor or disrupted sleep can impact our day-to-day performance. But circadian clocks are more than sleep/wake regulators—they are central to metabolic health. NAD levels are not only regulated by the circadian clock, but also help regulate its activity at a molecular level. [11-13]



CITATIONs

1. Bogan, K.L. and C. Brenner, Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr, 2008. 28: p. 115-30.

2. Belenky, P., K.L. Bogan, and C. Brenner, NAD+ metabolism in health and disease. Trends Biochem Sci, 2007. 32(1): p. 12-9.

3. Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13.

4. Fang, E.F., et al., NAD(+) in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med, 2017. 23(10): p. 899-916.

5. Canto, C., et al., The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47.

6. Zhang, H., et al., NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 2016. 352(6292): p. 1436-43.

7. Mouchiroud, L., et al., The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell, 2013. 154(2): p. 430-41.

8. Buono, M.J., Kolkhorst, F.W., Submitting Illuminations for review- Estimating ATP resynthesis during a marathon run: a method to introduce metabolism. Adv Phys Ed, 2001. 25(2): p. 70-71.

9. Goody, M.F. and C.A. Henry, A need for NAD+ in muscle development, homeostasis, and aging. Skelet Muscle, 2018. 8(1): p. 9.

10. Frederick, D.W., et al., Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab, 2016. 24(2): p. 269-82.

11. Nakahata, Y. and Y. Bessho, The Circadian NAD(+) Metabolism: Impact on Chromatin Remodeling and Aging. Biomed Res Int, 2016. 2016: p. 3208429.

12. Ramsey, K.M., et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science, 2009. 324(5927): p. 651-4.

13. Peek, C.B., et al., Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science, 2013. 342(6158): p. 1243417.

14. Trammell, S.A., et al., Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948.

15. Airhart, S.E., et al., An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. E0186459.

16. Martens, C.R., et al., Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286.

17. Dollerup, O.L., et al., A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.